The Neuroelectronics group develops biocompatible interfaces and sensor arrays for coupling tissue with electronics.

We design and fabricate bioelectronic interfaces and electrode arrays for neurotechnology and biosensors. In particular, we develop devices capable of stimulating and monitoring signals in neural or cardiac tissue. To this end, we use clean-room microfabrication, laser processing, and printing techniques for prototyping 3D transformable electrode arrays with soft, flexible, and biocompatible materials. 

Our applications focus on neural implants, non-invasive bioelectronics, and in vitro assays for investigating organoids and microfluidic cell culture systems. Recently, we have developed neuroelectronic devices that actively conform to the tissue structure's shape. Our devices can fold themselves around small peripheral nerves and provide a reliable connection to the tissue. This allows spatially and temporally resolved recording of electrophysiological signals along the nerve. At the same time, the nerve can be electrically stimulated to elicit a specific response of the innervated tissue. Using rapid prototyping techniques, we further develop 3D sensor systems that can be coupled with neuronal or cardiac organoids in a high-throughput manner. For example, micro-needle electrode arrays provide a means for continuously monitoring electrical activity within deeper layers of 3D cell assemblies. Overall, we aim to deliver long-term stable bioelectronic interfaces that can be used for closed-loop bidirectional communication and seamlessly integrate with the target tissue or organoid system. We complement these approaches with electrochemical and impedance-based detection strategies for biosensing applications.